Duke University: All brain activity studies are wrong

You know all those studies about brain activity? The ones that reveal thought patterns and feelings as a person performs a task? There’s a problem: The measurement they’re based on is inaccurate, according to a study out of Duke University that is rocking the field.

The trouble is that when the same person is asked to do the same tasks weeks or months apart, the results vary wildly. This is likely because fMRIs don’t actually measure brain activity directly: They measure blood flow to regions of the brain, which is used as a proxy for brain activity because neurons in those regions are presumably more active.

Blood flow levels, apparently, change. “The correlation between one scan and a second is not even fair, it’s poor,” says lead author Ahmad Hariri, a professor of neuroscience and psychology at Duke University.

The researchers reexamined 56 peer-reviewed, published papers that conducted 90 fMRI experiments, some by leaders in the field, and also looked at the results of so-called “test/retest” fMRIs, where 65 subjects were asked to do the same tasks months apart. They found that of seven measures of brain function, none had consistent readings.

This is a mouthful of dirt for hundreds of researchers—and Hariri is one of them. He has carried out fMRI research for 15 years, and is currently running a long-term fMRI study of 1,300 Duke students to discern why some come away from traumatic events with PTSD while others do not. “I’m going to throw myself under the bus,” he says. “This whole subbranch of fMRI could go extinct if we don’t address this critical limitation.”

Read more at www.fastcompany.com

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